<i>Nox</i>2 Deficiency Reduces Cartilage Damage and Ectopic Bone Formation in an Experimental Model for Osteoarthritis

<i>Nox</i>2 Deficiency Reduces Cartilage Damage and Ectopic Bone Formation in an Experimental Model for Osteoarthritis

Osteoarthritis (OA) is a destructive disease of the joint with age and obesity being its most important risk factors. Around 50% of OA patients suffer from inflammation of the synovial joint capsule, which is characterized by increased abundance and activation of synovial macrophages that produce re...

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Auteurs principaux: Nik N. L. Kruisbergen, Irene Di Ceglie, Yvonne van Gemert, Birgitte Walgreen, Monique M. A. Helsen, Annet W. Slöetjes, Marije I. Koenders, Fons A. J. van de Loo, Johannes Roth, Thomas Vogl, Peter M. van der Kraan, Arjen B. Blom, Peter L. E. M. van Lent, Martijn H. J. van den Bosch
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
osteoarthritis
ROS
Macrophages
NOX2
low-density lipoprotein
Therapeutics. Pharmacology
RM1-950
Accès en ligne:https://doaj.org/article/78cf3de17a744173a88dbeea58163c1d
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https://doaj.org/article/78cf3de17a744173a88dbeea58163c1d

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