LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal dermatitis in a LUBAC deficient murine model of dis...

Full description

Saved in:
Bibliographic Details
Main Authors: Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/78dd2d56aa01420b8690887b14510d40
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/78dd2d56aa01420b8690887b14510d40

Similar Items