LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal dermatitis in a LUBAC deficient murine model of dis...
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Nature Portfolio
2018
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oai:doaj.org-article:78dd2d56aa01420b8690887b14510d402021-12-02T17:32:44ZLUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L10.1038/s41467-018-06155-82041-1723https://doaj.org/article/78dd2d56aa01420b8690887b14510d402018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06155-8https://doaj.org/toc/2041-1723TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal dermatitis in a LUBAC deficient murine model of disease.Lucia TaraborrelliNieves PeltzerAntonella MontinaroSebastian KupkaEva RieserTorsten HartwigAida SarrMaurice DardingPeter DraberTobias L. HaasAyse AkarcaTeresa MarafiotiManolis PasparakisJohn BertinPeter J. GoughPhilippe BouilletAndreas StrasserMartin LeverkusJohn SilkeHenning WalczakNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lucia Taraborrelli Nieves Peltzer Antonella Montinaro Sebastian Kupka Eva Rieser Torsten Hartwig Aida Sarr Maurice Darding Peter Draber Tobias L. Haas Ayse Akarca Teresa Marafioti Manolis Pasparakis John Bertin Peter J. Gough Philippe Bouillet Andreas Strasser Martin Leverkus John Silke Henning Walczak LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L |
| description |
TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal dermatitis in a LUBAC deficient murine model of disease. |
| format |
article |
| author |
Lucia Taraborrelli Nieves Peltzer Antonella Montinaro Sebastian Kupka Eva Rieser Torsten Hartwig Aida Sarr Maurice Darding Peter Draber Tobias L. Haas Ayse Akarca Teresa Marafioti Manolis Pasparakis John Bertin Peter J. Gough Philippe Bouillet Andreas Strasser Martin Leverkus John Silke Henning Walczak |
| author_facet |
Lucia Taraborrelli Nieves Peltzer Antonella Montinaro Sebastian Kupka Eva Rieser Torsten Hartwig Aida Sarr Maurice Darding Peter Draber Tobias L. Haas Ayse Akarca Teresa Marafioti Manolis Pasparakis John Bertin Peter J. Gough Philippe Bouillet Andreas Strasser Martin Leverkus John Silke Henning Walczak |
| author_sort |
Lucia Taraborrelli |
| title |
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L |
| title_short |
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L |
| title_full |
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L |
| title_fullStr |
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L |
| title_full_unstemmed |
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L |
| title_sort |
lubac prevents lethal dermatitis by inhibiting cell death induced by tnf, trail and cd95l |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/78dd2d56aa01420b8690887b14510d40 |
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