Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics

Mitochondria are a hub that can direct cellular outcomes in response to stress. Here, the authors show that mitochondrial phosphatase PGAM5 has a role in mitochondrial turnover and regulation of cellular senescence by altering organellar dynamics via fission regulator Drp1.

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Autores principales:	Bo Yu, Jing Ma, Jing Li, Dazhi Wang, Zhigao Wang, Shusheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78f439af309a43a889952c8065a38027
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spelling	oai:doaj.org-article:78f439af309a43a889952c8065a380272021-12-02T15:45:25ZMitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics10.1038/s41467-020-16312-72041-1723https://doaj.org/article/78f439af309a43a889952c8065a380272020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16312-7https://doaj.org/toc/2041-1723Mitochondria are a hub that can direct cellular outcomes in response to stress. Here, the authors show that mitochondrial phosphatase PGAM5 has a role in mitochondrial turnover and regulation of cellular senescence by altering organellar dynamics via fission regulator Drp1.Bo YuJing MaJing LiDazhi WangZhigao WangShusheng WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo Yu Jing Ma Jing Li Dazhi Wang Zhigao Wang Shusheng Wang Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics
description	Mitochondria are a hub that can direct cellular outcomes in response to stress. Here, the authors show that mitochondrial phosphatase PGAM5 has a role in mitochondrial turnover and regulation of cellular senescence by altering organellar dynamics via fission regulator Drp1.
format	article
author	Bo Yu Jing Ma Jing Li Dazhi Wang Zhigao Wang Shusheng Wang
author_facet	Bo Yu Jing Ma Jing Li Dazhi Wang Zhigao Wang Shusheng Wang
author_sort	Bo Yu
title	Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics
title_short	Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics
title_full	Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics
title_fullStr	Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics
title_full_unstemmed	Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics
title_sort	mitochondrial phosphatase pgam5 modulates cellular senescence by regulating mitochondrial dynamics
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/78f439af309a43a889952c8065a38027
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_version_	1718385758874632192

Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics

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