Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity

Abstract Docosahexaenoic acid (DHA, 22:6 n-3) is abundant in the retina and is enzymatically converted into pro-homeostatic docosanoids. The DHA- or eicosapentaenoic acid (EPA)-derived 26 carbon fatty acid is a substrate of elongase ELOVL4, which is expressed in photoreceptor cells and generates ver...

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Autores principales: Bokkyoo Jun, Pranab K. Mukherjee, Aram Asatryan, Marie-Audrey Kautzmann, Jessica Heap, William C. Gordon, Surjyadipta Bhattacharjee, Rong Yang, Nicos A. Petasis, Nicolas G. Bazan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/78f8ad6d48ad4ead8958b0ab446f4c81
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