mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division

mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division

mTOR activation is known to generate polycystic kidneys, which show both increased proliferation and loss of oriented cell division (OCD). Here, Bonucci et al. show that loss of OCD is linked to S6K1 activation through its direct target Afadin and is separable from hyperproliferation.

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Detalles Bibliográficos
Autores principales: Martina Bonucci, Nicolas Kuperwasser, Serena Barbe, Vonda Koka, Delphine de Villeneuve, Chi Zhang, Nishit Srivastava, Xiaoying Jia, Matthew P. Stokes, Frank Bienaimé, Virginie Verkarre, Jean Baptiste Lopez, Fanny Jaulin, Marco Pontoglio, Fabiola Terzi, Benedicte Delaval, Matthieu Piel, Mario Pende
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/7932503fbce7452fbc9e9d545274ef7a
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https://doaj.org/article/7932503fbce7452fbc9e9d545274ef7a

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