mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division
mTOR activation is known to generate polycystic kidneys, which show both increased proliferation and loss of oriented cell division (OCD). Here, Bonucci et al. show that loss of OCD is linked to S6K1 activation through its direct target Afadin and is separable from hyperproliferation.
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Nature Portfolio
2020
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oai:doaj.org-article:7932503fbce7452fbc9e9d545274ef7a2021-12-02T17:45:09ZmTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division10.1038/s41467-020-16978-z2041-1723https://doaj.org/article/7932503fbce7452fbc9e9d545274ef7a2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16978-zhttps://doaj.org/toc/2041-1723mTOR activation is known to generate polycystic kidneys, which show both increased proliferation and loss of oriented cell division (OCD). Here, Bonucci et al. show that loss of OCD is linked to S6K1 activation through its direct target Afadin and is separable from hyperproliferation.Martina BonucciNicolas KuperwasserSerena BarbeVonda KokaDelphine de VilleneuveChi ZhangNishit SrivastavaXiaoying JiaMatthew P. StokesFrank BienaiméVirginie VerkarreJean Baptiste LopezFanny JaulinMarco PontoglioFabiola TerziBenedicte DelavalMatthieu PielMario PendeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Martina Bonucci Nicolas Kuperwasser Serena Barbe Vonda Koka Delphine de Villeneuve Chi Zhang Nishit Srivastava Xiaoying Jia Matthew P. Stokes Frank Bienaimé Virginie Verkarre Jean Baptiste Lopez Fanny Jaulin Marco Pontoglio Fabiola Terzi Benedicte Delaval Matthieu Piel Mario Pende mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division |
| description |
mTOR activation is known to generate polycystic kidneys, which show both increased proliferation and loss of oriented cell division (OCD). Here, Bonucci et al. show that loss of OCD is linked to S6K1 activation through its direct target Afadin and is separable from hyperproliferation. |
| format |
article |
| author |
Martina Bonucci Nicolas Kuperwasser Serena Barbe Vonda Koka Delphine de Villeneuve Chi Zhang Nishit Srivastava Xiaoying Jia Matthew P. Stokes Frank Bienaimé Virginie Verkarre Jean Baptiste Lopez Fanny Jaulin Marco Pontoglio Fabiola Terzi Benedicte Delaval Matthieu Piel Mario Pende |
| author_facet |
Martina Bonucci Nicolas Kuperwasser Serena Barbe Vonda Koka Delphine de Villeneuve Chi Zhang Nishit Srivastava Xiaoying Jia Matthew P. Stokes Frank Bienaimé Virginie Verkarre Jean Baptiste Lopez Fanny Jaulin Marco Pontoglio Fabiola Terzi Benedicte Delaval Matthieu Piel Mario Pende |
| author_sort |
Martina Bonucci |
| title |
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division |
| title_short |
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division |
| title_full |
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division |
| title_fullStr |
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division |
| title_full_unstemmed |
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division |
| title_sort |
mtor and s6k1 drive polycystic kidney by the control of afadin-dependent oriented cell division |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/7932503fbce7452fbc9e9d545274ef7a |
| work_keys_str_mv |
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| _version_ |
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