Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism

Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism

Anti-VEGF therapy often produces limited beneficial effects in cancer patients. Here, the authors show that discontinuation of anti-VEGF cancer therapy in xenografts-bearing mice increases cancer cells extravasation and intravasation in liver through the host-derived VEGF.

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Bibliographic Details
Main Authors: Yunlong Yang, Yin Zhang, Hideki Iwamoto, Kayoko Hosaka, Takahiro Seki, Patrik Andersson, Sharon Lim, Carina Fischer, Masaki Nakamura, Mitsuhiko Abe, Renhai Cao, Peter Vilhelm Skov, Fang Chen, Xiaoyun Chen, Yongtian Lu, Guohui Nie, Yihai Cao
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/79582752f03043d7b3b6d8145bb72174
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Internet

https://doaj.org/article/79582752f03043d7b3b6d8145bb72174

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