Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism
Anti-VEGF therapy often produces limited beneficial effects in cancer patients. Here, the authors show that discontinuation of anti-VEGF cancer therapy in xenografts-bearing mice increases cancer cells extravasation and intravasation in liver through the host-derived VEGF.
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Nature Portfolio
2016
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oai:doaj.org-article:79582752f03043d7b3b6d8145bb721742021-12-02T17:31:50ZDiscontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism10.1038/ncomms126802041-1723https://doaj.org/article/79582752f03043d7b3b6d8145bb721742016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12680https://doaj.org/toc/2041-1723Anti-VEGF therapy often produces limited beneficial effects in cancer patients. Here, the authors show that discontinuation of anti-VEGF cancer therapy in xenografts-bearing mice increases cancer cells extravasation and intravasation in liver through the host-derived VEGF.Yunlong YangYin ZhangHideki IwamotoKayoko HosakaTakahiro SekiPatrik AnderssonSharon LimCarina FischerMasaki NakamuraMitsuhiko AbeRenhai CaoPeter Vilhelm SkovFang ChenXiaoyun ChenYongtian LuGuohui NieYihai CaoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
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Science Q |
spellingShingle |
Science Q Yunlong Yang Yin Zhang Hideki Iwamoto Kayoko Hosaka Takahiro Seki Patrik Andersson Sharon Lim Carina Fischer Masaki Nakamura Mitsuhiko Abe Renhai Cao Peter Vilhelm Skov Fang Chen Xiaoyun Chen Yongtian Lu Guohui Nie Yihai Cao Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism |
description |
Anti-VEGF therapy often produces limited beneficial effects in cancer patients. Here, the authors show that discontinuation of anti-VEGF cancer therapy in xenografts-bearing mice increases cancer cells extravasation and intravasation in liver through the host-derived VEGF. |
format |
article |
author |
Yunlong Yang Yin Zhang Hideki Iwamoto Kayoko Hosaka Takahiro Seki Patrik Andersson Sharon Lim Carina Fischer Masaki Nakamura Mitsuhiko Abe Renhai Cao Peter Vilhelm Skov Fang Chen Xiaoyun Chen Yongtian Lu Guohui Nie Yihai Cao |
author_facet |
Yunlong Yang Yin Zhang Hideki Iwamoto Kayoko Hosaka Takahiro Seki Patrik Andersson Sharon Lim Carina Fischer Masaki Nakamura Mitsuhiko Abe Renhai Cao Peter Vilhelm Skov Fang Chen Xiaoyun Chen Yongtian Lu Guohui Nie Yihai Cao |
author_sort |
Yunlong Yang |
title |
Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism |
title_short |
Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism |
title_full |
Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism |
title_fullStr |
Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism |
title_full_unstemmed |
Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism |
title_sort |
discontinuation of anti-vegf cancer therapy promotes metastasis through a liver revascularization mechanism |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/79582752f03043d7b3b6d8145bb72174 |
work_keys_str_mv |
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