Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification

Chemical cross-linking combined with mass spectrometry (XL-MS) can provide information on protein conformations and interactions in highly complex samples. Here the authors describe an improved XL-MS workflow to increase the depth and fidelity of cross-link identification using whole proteome databa...

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Autores principales: Fan Liu, Philip Lössl, Richard Scheltema, Rosa Viner, Albert J. R. Heck
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/795c6d6e96bb403090ddd88fdd2c3e71
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