Viral perturbations of host networks reflect disease etiology.
Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine whether viral perturbations of host interactome may...
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Public Library of Science (PLoS)
2012
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oai:doaj.org-article:799864a4ab4c4db9b486151cf21f32a52021-11-18T05:51:14ZViral perturbations of host networks reflect disease etiology.1553-734X1553-735810.1371/journal.pcbi.1002531https://doaj.org/article/799864a4ab4c4db9b486151cf21f32a52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22761553/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine whether viral perturbations of host interactome may underlie such virally implicated disease relationships. Using as models two different human viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), we find that host targets of viral proteins reside in network proximity to products of disease susceptibility genes. Expression changes in virally implicated disease tissues and comorbidity patterns cluster significantly in the network vicinity of viral targets. The topological proximity found between cellular targets of viral proteins and disease genes was exploited to uncover a novel pathway linking HPV to Fanconi anemia.Natali GulbahceHan YanAmélie DricotMegha PadiDanielle ByrdsongRachel FranchiDeok-Sun LeeOrit Rozenblatt-RosenJessica C MarMichael A CalderwoodAmy BaldwinBo ZhaoBalaji SanthanamPascal BraunNicolas SimonisKyung-Won HuhKarin HellnerMiranda GraceAlyce ChenRenee RubioJarrod A MartoNicholas A ChristakisElliott KieffFrederick P RothJennifer Roecklein-CanfieldJames A DecaprioMichael E CusickJohn QuackenbushDavid E HillKarl MüngerMarc VidalAlbert-László BarabásiPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 6, p e1002531 (2012) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Natali Gulbahce Han Yan Amélie Dricot Megha Padi Danielle Byrdsong Rachel Franchi Deok-Sun Lee Orit Rozenblatt-Rosen Jessica C Mar Michael A Calderwood Amy Baldwin Bo Zhao Balaji Santhanam Pascal Braun Nicolas Simonis Kyung-Won Huh Karin Hellner Miranda Grace Alyce Chen Renee Rubio Jarrod A Marto Nicholas A Christakis Elliott Kieff Frederick P Roth Jennifer Roecklein-Canfield James A Decaprio Michael E Cusick John Quackenbush David E Hill Karl Münger Marc Vidal Albert-László Barabási Viral perturbations of host networks reflect disease etiology. |
| description |
Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine whether viral perturbations of host interactome may underlie such virally implicated disease relationships. Using as models two different human viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), we find that host targets of viral proteins reside in network proximity to products of disease susceptibility genes. Expression changes in virally implicated disease tissues and comorbidity patterns cluster significantly in the network vicinity of viral targets. The topological proximity found between cellular targets of viral proteins and disease genes was exploited to uncover a novel pathway linking HPV to Fanconi anemia. |
| format |
article |
| author |
Natali Gulbahce Han Yan Amélie Dricot Megha Padi Danielle Byrdsong Rachel Franchi Deok-Sun Lee Orit Rozenblatt-Rosen Jessica C Mar Michael A Calderwood Amy Baldwin Bo Zhao Balaji Santhanam Pascal Braun Nicolas Simonis Kyung-Won Huh Karin Hellner Miranda Grace Alyce Chen Renee Rubio Jarrod A Marto Nicholas A Christakis Elliott Kieff Frederick P Roth Jennifer Roecklein-Canfield James A Decaprio Michael E Cusick John Quackenbush David E Hill Karl Münger Marc Vidal Albert-László Barabási |
| author_facet |
Natali Gulbahce Han Yan Amélie Dricot Megha Padi Danielle Byrdsong Rachel Franchi Deok-Sun Lee Orit Rozenblatt-Rosen Jessica C Mar Michael A Calderwood Amy Baldwin Bo Zhao Balaji Santhanam Pascal Braun Nicolas Simonis Kyung-Won Huh Karin Hellner Miranda Grace Alyce Chen Renee Rubio Jarrod A Marto Nicholas A Christakis Elliott Kieff Frederick P Roth Jennifer Roecklein-Canfield James A Decaprio Michael E Cusick John Quackenbush David E Hill Karl Münger Marc Vidal Albert-László Barabási |
| author_sort |
Natali Gulbahce |
| title |
Viral perturbations of host networks reflect disease etiology. |
| title_short |
Viral perturbations of host networks reflect disease etiology. |
| title_full |
Viral perturbations of host networks reflect disease etiology. |
| title_fullStr |
Viral perturbations of host networks reflect disease etiology. |
| title_full_unstemmed |
Viral perturbations of host networks reflect disease etiology. |
| title_sort |
viral perturbations of host networks reflect disease etiology. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/799864a4ab4c4db9b486151cf21f32a5 |
| work_keys_str_mv |
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