Bcl-2 is a critical mediator of intestinal transformation

Bcl-2 is a critical mediator of intestinal transformation

The anti-apoptotic protein Bcl-2 is selectively expressed in intestinal stem cells (ISCs). Here, the authors show that, in intestinal stem cells, Bcl-2 alleviates apoptotic priming induced by the loss of the tumour suppressor Apc in ISCs and that the absence of Bcl-2 or pharmacological blockade of B...

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Autores principales: Maartje van der Heijden, Cheryl D. Zimberlin, Anna M. Nicholson, Selcuk Colak, Richard Kemp, Sybren L. Meijer, Jan Paul Medema, Florian R. Greten, Marnix Jansen, Douglas J. Winton, Louis Vermeulen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/79fa743e4cb74ee29cb645e41f5d7283
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https://doaj.org/article/79fa743e4cb74ee29cb645e41f5d7283

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