Bcl-2 is a critical mediator of intestinal transformation

The anti-apoptotic protein Bcl-2 is selectively expressed in intestinal stem cells (ISCs). Here, the authors show that, in intestinal stem cells, Bcl-2 alleviates apoptotic priming induced by the loss of the tumour suppressor Apc in ISCs and that the absence of Bcl-2 or pharmacological blockade of B...

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Autores principales:	Maartje van der Heijden, Cheryl D. Zimberlin, Anna M. Nicholson, Selcuk Colak, Richard Kemp, Sybren L. Meijer, Jan Paul Medema, Florian R. Greten, Marnix Jansen, Douglas J. Winton, Louis Vermeulen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79fa743e4cb74ee29cb645e41f5d7283
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spelling	oai:doaj.org-article:79fa743e4cb74ee29cb645e41f5d72832021-12-02T15:35:01ZBcl-2 is a critical mediator of intestinal transformation10.1038/ncomms109162041-1723https://doaj.org/article/79fa743e4cb74ee29cb645e41f5d72832016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10916https://doaj.org/toc/2041-1723The anti-apoptotic protein Bcl-2 is selectively expressed in intestinal stem cells (ISCs). Here, the authors show that, in intestinal stem cells, Bcl-2 alleviates apoptotic priming induced by the loss of the tumour suppressor Apc in ISCs and that the absence of Bcl-2 or pharmacological blockade of Bcl-2 can inhibit the intestinal tumorigenesis driven by the Apc-loss.Maartje van der HeijdenCheryl D. ZimberlinAnna M. NicholsonSelcuk ColakRichard KempSybren L. MeijerJan Paul MedemaFlorian R. GretenMarnix JansenDouglas J. WintonLouis VermeulenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maartje van der Heijden Cheryl D. Zimberlin Anna M. Nicholson Selcuk Colak Richard Kemp Sybren L. Meijer Jan Paul Medema Florian R. Greten Marnix Jansen Douglas J. Winton Louis Vermeulen Bcl-2 is a critical mediator of intestinal transformation
description	The anti-apoptotic protein Bcl-2 is selectively expressed in intestinal stem cells (ISCs). Here, the authors show that, in intestinal stem cells, Bcl-2 alleviates apoptotic priming induced by the loss of the tumour suppressor Apc in ISCs and that the absence of Bcl-2 or pharmacological blockade of Bcl-2 can inhibit the intestinal tumorigenesis driven by the Apc-loss.
format	article
author	Maartje van der Heijden Cheryl D. Zimberlin Anna M. Nicholson Selcuk Colak Richard Kemp Sybren L. Meijer Jan Paul Medema Florian R. Greten Marnix Jansen Douglas J. Winton Louis Vermeulen
author_facet	Maartje van der Heijden Cheryl D. Zimberlin Anna M. Nicholson Selcuk Colak Richard Kemp Sybren L. Meijer Jan Paul Medema Florian R. Greten Marnix Jansen Douglas J. Winton Louis Vermeulen
author_sort	Maartje van der Heijden
title	Bcl-2 is a critical mediator of intestinal transformation
title_short	Bcl-2 is a critical mediator of intestinal transformation
title_full	Bcl-2 is a critical mediator of intestinal transformation
title_fullStr	Bcl-2 is a critical mediator of intestinal transformation
title_full_unstemmed	Bcl-2 is a critical mediator of intestinal transformation
title_sort	bcl-2 is a critical mediator of intestinal transformation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/79fa743e4cb74ee29cb645e41f5d7283
work_keys_str_mv	AT maartjevanderheijden bcl2isacriticalmediatorofintestinaltransformation AT cheryldzimberlin bcl2isacriticalmediatorofintestinaltransformation AT annamnicholson bcl2isacriticalmediatorofintestinaltransformation AT selcukcolak bcl2isacriticalmediatorofintestinaltransformation AT richardkemp bcl2isacriticalmediatorofintestinaltransformation AT sybrenlmeijer bcl2isacriticalmediatorofintestinaltransformation AT janpaulmedema bcl2isacriticalmediatorofintestinaltransformation AT florianrgreten bcl2isacriticalmediatorofintestinaltransformation AT marnixjansen bcl2isacriticalmediatorofintestinaltransformation AT douglasjwinton bcl2isacriticalmediatorofintestinaltransformation AT louisvermeulen bcl2isacriticalmediatorofintestinaltransformation
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Bcl-2 is a critical mediator of intestinal transformation

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