Promoter hypermethylation inactivates CDKN2A, CDKN2B and RASSF1A genes in sporadic parathyroid adenomas

Promoter hypermethylation inactivates CDKN2A, CDKN2B and RASSF1A genes in sporadic parathyroid adenomas

Abstract Cyclin D1, a G1-S phase regulator, is upregulated in parathyroid adenomas. Since cyclin-dependent kinase (CDK) inhibitors, CDKN2A and CDKN2B, and RASSF1A (Ras-association domain family 1, isoform A) are involved in G1-S phase arrest and act as potential tumor suppressor genes, we aimed to s...

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Main Authors: Ashutosh Kumar Arya, Sanjay Kumar Bhadada, Priyanka Singh, Naresh Sachdeva, Uma Nahar Saikia, Divya Dahiya, Arunanshu Behera, Anil Bhansali, Sudhaker D. Rao
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/7a07776f1a83430da8cbd57ec4cd330f
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