Adenosine A2A receptor signaling promotes FoxO associated autophagy in chondrocytes

Abstract Autophagy, a homeostatic pathway upregulated during cellular stress, is decreased in osteoarthritic chondrocytes and this reduction in autophagy is thought to contribute to the development and progression of osteoarthritis (OA). The adenosine A2A receptor (A2AR) is a potent anti-inflammator...

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Autores principales: Benjamin Friedman, Carmen Corciulo, Cristina M. Castro, Bruce N. Cronstein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7a28cadbee7746b4b032c27613f2cde2
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