Adenosine A2A receptor signaling promotes FoxO associated autophagy in chondrocytes

Abstract Autophagy, a homeostatic pathway upregulated during cellular stress, is decreased in osteoarthritic chondrocytes and this reduction in autophagy is thought to contribute to the development and progression of osteoarthritis (OA). The adenosine A2A receptor (A2AR) is a potent anti-inflammator...

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Bibliographic Details
Main Authors: Benjamin Friedman, Carmen Corciulo, Cristina M. Castro, Bruce N. Cronstein
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/7a28cadbee7746b4b032c27613f2cde2
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