Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine

Overuse or overconsumption of food additive or colorant cannot be ignored in our society and there are several reports of it harmful effect on the body system. This study investigated the toxicity effect of tartrazine and erythrosine (ET, 50:50) on neurobehavioral alteration, striatal oxido-nitrosat...

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Autores principales:	Iheanyichukwu Wopara, Olusegun G. Adebayo, Elizabeth B. Umoren, Wadioni Aduema, Adaku V. Iwueke, O.E. Etim, Egelege Aziemeola. Pius, Woha Boobondah James, Joel Wodo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Tartrazine and erythrosine Oxidative stress Nitrosative stress Pro-inflammatory cytokine Acetylcholinesterase Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/7a2d96a637a343da883c9a7170fad5ee
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spelling	oai:doaj.org-article:7a2d96a637a343da883c9a7170fad5ee2021-12-02T05:03:17ZInvolvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine2405-844010.1016/j.heliyon.2021.e08454https://doaj.org/article/7a2d96a637a343da883c9a7170fad5ee2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021025573https://doaj.org/toc/2405-8440Overuse or overconsumption of food additive or colorant cannot be ignored in our society and there are several reports of it harmful effect on the body system. This study investigated the toxicity effect of tartrazine and erythrosine (ET, 50:50) on neurobehavioral alteration, striatal oxido-nitrosative and pro-inflammatory stress and striatal acetylcholinesterase activity in experimental rat model. Rats were co-exposed to ET (2 mg/kg, 6 mg/kg and 10 mg/kg) and distilled water (control), p.o for 6 weeks. The change in neurobehavioral function (Open field test, Forced swimming test and Tail suspension test), Lipid peroxidation (Malonaldehyde, MDA), Antioxidants (Glutathione, GSH; Catalase, CAT) Nitrite, Pro-inflammatory cytokine (Tumor necrosis factor-alpha, TNF-α) and Acetylcholinesterase (AChE) activity were evaluated. Results showed significant decrease in neurobehavioral functions after co-exposure to ET. Moreover, there were significant increase in MDA and Nitrite level, significant decrease in the concentration of GSH and CAT and a significant increase TNF-α concentration and AChE activity after co-exposure to ET. Oral co-exposure to tartrazine and erythrosine induced decrease in locomotion and exploration, increase anxiety and depression-like behavior and altered the cholinergic system through upregulation of oxido-nitrosative stress, pro-inflammatory cytokine and acetylcholinesterase activity.Iheanyichukwu WoparaOlusegun G. AdebayoElizabeth B. UmorenWadioni AduemaAdaku V. IwuekeO.E. EtimEgelege Aziemeola. PiusWoha Boobondah JamesJoel WodoElsevierarticleTartrazine and erythrosineOxidative stressNitrosative stressPro-inflammatory cytokineAcetylcholinesteraseScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08454- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tartrazine and erythrosine Oxidative stress Nitrosative stress Pro-inflammatory cytokine Acetylcholinesterase Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Tartrazine and erythrosine Oxidative stress Nitrosative stress Pro-inflammatory cytokine Acetylcholinesterase Science (General) Q1-390 Social sciences (General) H1-99 Iheanyichukwu Wopara Olusegun G. Adebayo Elizabeth B. Umoren Wadioni Aduema Adaku V. Iwueke O.E. Etim Egelege Aziemeola. Pius Woha Boobondah James Joel Wodo Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine
description	Overuse or overconsumption of food additive or colorant cannot be ignored in our society and there are several reports of it harmful effect on the body system. This study investigated the toxicity effect of tartrazine and erythrosine (ET, 50:50) on neurobehavioral alteration, striatal oxido-nitrosative and pro-inflammatory stress and striatal acetylcholinesterase activity in experimental rat model. Rats were co-exposed to ET (2 mg/kg, 6 mg/kg and 10 mg/kg) and distilled water (control), p.o for 6 weeks. The change in neurobehavioral function (Open field test, Forced swimming test and Tail suspension test), Lipid peroxidation (Malonaldehyde, MDA), Antioxidants (Glutathione, GSH; Catalase, CAT) Nitrite, Pro-inflammatory cytokine (Tumor necrosis factor-alpha, TNF-α) and Acetylcholinesterase (AChE) activity were evaluated. Results showed significant decrease in neurobehavioral functions after co-exposure to ET. Moreover, there were significant increase in MDA and Nitrite level, significant decrease in the concentration of GSH and CAT and a significant increase TNF-α concentration and AChE activity after co-exposure to ET. Oral co-exposure to tartrazine and erythrosine induced decrease in locomotion and exploration, increase anxiety and depression-like behavior and altered the cholinergic system through upregulation of oxido-nitrosative stress, pro-inflammatory cytokine and acetylcholinesterase activity.
format	article
author	Iheanyichukwu Wopara Olusegun G. Adebayo Elizabeth B. Umoren Wadioni Aduema Adaku V. Iwueke O.E. Etim Egelege Aziemeola. Pius Woha Boobondah James Joel Wodo
author_facet	Iheanyichukwu Wopara Olusegun G. Adebayo Elizabeth B. Umoren Wadioni Aduema Adaku V. Iwueke O.E. Etim Egelege Aziemeola. Pius Woha Boobondah James Joel Wodo
author_sort	Iheanyichukwu Wopara
title	Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine
title_short	Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine
title_full	Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine
title_fullStr	Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine
title_full_unstemmed	Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine
title_sort	involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7a2d96a637a343da883c9a7170fad5ee
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Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine

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