Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis

Internalized receptors are recycled back to the cell surface, but their precise mechanisms are unclear. Here, the authors show that the flotillin membrane proteins may regulate the transfer of internalized T cell receptors into Rab5 and Rab11-positive endosomes to support its rapid recycling.

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Autores principales: Gregory M. I. Redpath, Manuela Ecker, Natasha Kapoor-Kaushik, Haig Vartoukian, Michael Carnell, Daryan Kempe, Maté Biro, Nicholas Ariotti, Jérémie Rossy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7a443cee32e1488c8af56115215e2eb5
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