Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis

Internalized receptors are recycled back to the cell surface, but their precise mechanisms are unclear. Here, the authors show that the flotillin membrane proteins may regulate the transfer of internalized T cell receptors into Rab5 and Rab11-positive endosomes to support its rapid recycling.

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Autores principales:	Gregory M. I. Redpath, Manuela Ecker, Natasha Kapoor-Kaushik, Haig Vartoukian, Michael Carnell, Daryan Kempe, Maté Biro, Nicholas Ariotti, Jérémie Rossy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a443cee32e1488c8af56115215e2eb5
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spelling	oai:doaj.org-article:7a443cee32e1488c8af56115215e2eb52021-12-02T15:36:22ZFlotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis10.1038/s41467-019-12352-w2041-1723https://doaj.org/article/7a443cee32e1488c8af56115215e2eb52019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12352-whttps://doaj.org/toc/2041-1723Internalized receptors are recycled back to the cell surface, but their precise mechanisms are unclear. Here, the authors show that the flotillin membrane proteins may regulate the transfer of internalized T cell receptors into Rab5 and Rab11-positive endosomes to support its rapid recycling.Gregory M. I. RedpathManuela EckerNatasha Kapoor-KaushikHaig VartoukianMichael CarnellDaryan KempeMaté BiroNicholas AriottiJérémie RossyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gregory M. I. Redpath Manuela Ecker Natasha Kapoor-Kaushik Haig Vartoukian Michael Carnell Daryan Kempe Maté Biro Nicholas Ariotti Jérémie Rossy Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis
description	Internalized receptors are recycled back to the cell surface, but their precise mechanisms are unclear. Here, the authors show that the flotillin membrane proteins may regulate the transfer of internalized T cell receptors into Rab5 and Rab11-positive endosomes to support its rapid recycling.
format	article
author	Gregory M. I. Redpath Manuela Ecker Natasha Kapoor-Kaushik Haig Vartoukian Michael Carnell Daryan Kempe Maté Biro Nicholas Ariotti Jérémie Rossy
author_facet	Gregory M. I. Redpath Manuela Ecker Natasha Kapoor-Kaushik Haig Vartoukian Michael Carnell Daryan Kempe Maté Biro Nicholas Ariotti Jérémie Rossy
author_sort	Gregory M. I. Redpath
title	Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis
title_short	Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis
title_full	Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis
title_fullStr	Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis
title_full_unstemmed	Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis
title_sort	flotillins promote t cell receptor sorting through a fast rab5–rab11 endocytic recycling axis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7a443cee32e1488c8af56115215e2eb5
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Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis

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