Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses
Abstract Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is a ketone body and has recently been reported to exert anti-inflammatory effects via inhibition of NLRP3 inflammasome. Here, we investigated the potential antidepressant...
Saved in:
Main Authors: | Takehiko Yamanashi, Masaaki Iwata, Naho Kamiya, Kyohei Tsunetomi, Naofumi Kajitani, Nodoka Wada, Takahiro Iitsuka, Takahira Yamauchi, Akihiko Miura, Shenghong Pu, Yukihiko Shirayama, Ken Watanabe, Ronald S. Duman, Koichi Kaneko |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2017
|
Subjects: | |
Online Access: | https://doaj.org/article/7a47716c1b5542f2802d09eae4f2cab7 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
by: Takehiko Yamanashi, et al.
Published: (2020) -
Artificial polyhydroxyalkanoate poly[2-hydroxybutyrate-block-3-hydroxybutyrate] elastomer-like material
by: Yuki Kageyama, et al.
Published: (2021) -
Spotlight on the NLRP3 inflammasome pathway
by: Groslambert M, et al.
Published: (2018) -
The role of the NLRP3 inflammasome in gout
by: Sarah R Kingsbury, et al.
Published: (2011) -
Ketone body 3-hydroxybutyrate as a biomarker of aggression
by: A. M. Whipp, et al.
Published: (2021)