Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4

Obesity can affect bone marrow cell differentiation and the generation of myeloid and lymphoid cells. Here, the authors show that diet and obesity, as well as low-dose lipopolysaccharide, can alter Toll-like receptor 4 signaling bone marrow cells to skew the myeloid-lymphoid homeostasis in mice.

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Autores principales:	Ailing Liu, Minhui Chen, Rashmi Kumar, Maja Stefanovic-Racic, Robert M. O’Doherty, Ying Ding, Willi Jahnen-Dechent, Lisa Borghesi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a728719f6124ecf8609d688530588a3
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spelling	oai:doaj.org-article:7a728719f6124ecf8609d688530588a32021-12-02T14:41:16ZBone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR410.1038/s41467-018-03145-82041-1723https://doaj.org/article/7a728719f6124ecf8609d688530588a32018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03145-8https://doaj.org/toc/2041-1723Obesity can affect bone marrow cell differentiation and the generation of myeloid and lymphoid cells. Here, the authors show that diet and obesity, as well as low-dose lipopolysaccharide, can alter Toll-like receptor 4 signaling bone marrow cells to skew the myeloid-lymphoid homeostasis in mice.Ailing LiuMinhui ChenRashmi KumarMaja Stefanovic-RacicRobert M. O’DohertyYing DingWilli Jahnen-DechentLisa BorghesiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ailing Liu Minhui Chen Rashmi Kumar Maja Stefanovic-Racic Robert M. O’Doherty Ying Ding Willi Jahnen-Dechent Lisa Borghesi Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4
description	Obesity can affect bone marrow cell differentiation and the generation of myeloid and lymphoid cells. Here, the authors show that diet and obesity, as well as low-dose lipopolysaccharide, can alter Toll-like receptor 4 signaling bone marrow cells to skew the myeloid-lymphoid homeostasis in mice.
format	article
author	Ailing Liu Minhui Chen Rashmi Kumar Maja Stefanovic-Racic Robert M. O’Doherty Ying Ding Willi Jahnen-Dechent Lisa Borghesi
author_facet	Ailing Liu Minhui Chen Rashmi Kumar Maja Stefanovic-Racic Robert M. O’Doherty Ying Ding Willi Jahnen-Dechent Lisa Borghesi
author_sort	Ailing Liu
title	Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4
title_short	Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4
title_full	Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4
title_fullStr	Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4
title_full_unstemmed	Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4
title_sort	bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous tlr4
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7a728719f6124ecf8609d688530588a3
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Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4

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