ULK1 phosphorylates Exo70 to suppress breast cancer metastasis

Elevated expression of ULK1 is known to be inversely correlated with breast cancer metastasis. Here, the authors report Exo70 as a substrate of ULK1 that suppresses cancer metastasis, and show that ERK1/2 mediated phosphorylation of Exo70 leads to opposing effects on tumour cell invasion.

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Autores principales:	Liyuan Mao, Yan-yan Zhan, Bin Wu, Qiang Yu, Liang Xu, Xiaoting Hong, Linhai Zhong, Panying Mi, Li Xiao, Xinquan Wang, Hanwei Cao, Wenqing Zhang, Binbin Chen, Jingzhou Xiang, Kunrong Mei, Ravi Radhakrishnan, Wei Guo, Tianhui Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a8d91e583c5427ba8f9a268e2cf0b5b
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spelling	oai:doaj.org-article:7a8d91e583c5427ba8f9a268e2cf0b5b2021-12-02T17:31:39ZULK1 phosphorylates Exo70 to suppress breast cancer metastasis10.1038/s41467-019-13923-72041-1723https://doaj.org/article/7a8d91e583c5427ba8f9a268e2cf0b5b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13923-7https://doaj.org/toc/2041-1723Elevated expression of ULK1 is known to be inversely correlated with breast cancer metastasis. Here, the authors report Exo70 as a substrate of ULK1 that suppresses cancer metastasis, and show that ERK1/2 mediated phosphorylation of Exo70 leads to opposing effects on tumour cell invasion.Liyuan MaoYan-yan ZhanBin WuQiang YuLiang XuXiaoting HongLinhai ZhongPanying MiLi XiaoXinquan WangHanwei CaoWenqing ZhangBinbin ChenJingzhou XiangKunrong MeiRavi RadhakrishnanWei GuoTianhui HuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liyuan Mao Yan-yan Zhan Bin Wu Qiang Yu Liang Xu Xiaoting Hong Linhai Zhong Panying Mi Li Xiao Xinquan Wang Hanwei Cao Wenqing Zhang Binbin Chen Jingzhou Xiang Kunrong Mei Ravi Radhakrishnan Wei Guo Tianhui Hu ULK1 phosphorylates Exo70 to suppress breast cancer metastasis
description	Elevated expression of ULK1 is known to be inversely correlated with breast cancer metastasis. Here, the authors report Exo70 as a substrate of ULK1 that suppresses cancer metastasis, and show that ERK1/2 mediated phosphorylation of Exo70 leads to opposing effects on tumour cell invasion.
format	article
author	Liyuan Mao Yan-yan Zhan Bin Wu Qiang Yu Liang Xu Xiaoting Hong Linhai Zhong Panying Mi Li Xiao Xinquan Wang Hanwei Cao Wenqing Zhang Binbin Chen Jingzhou Xiang Kunrong Mei Ravi Radhakrishnan Wei Guo Tianhui Hu
author_facet	Liyuan Mao Yan-yan Zhan Bin Wu Qiang Yu Liang Xu Xiaoting Hong Linhai Zhong Panying Mi Li Xiao Xinquan Wang Hanwei Cao Wenqing Zhang Binbin Chen Jingzhou Xiang Kunrong Mei Ravi Radhakrishnan Wei Guo Tianhui Hu
author_sort	Liyuan Mao
title	ULK1 phosphorylates Exo70 to suppress breast cancer metastasis
title_short	ULK1 phosphorylates Exo70 to suppress breast cancer metastasis
title_full	ULK1 phosphorylates Exo70 to suppress breast cancer metastasis
title_fullStr	ULK1 phosphorylates Exo70 to suppress breast cancer metastasis
title_full_unstemmed	ULK1 phosphorylates Exo70 to suppress breast cancer metastasis
title_sort	ulk1 phosphorylates exo70 to suppress breast cancer metastasis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7a8d91e583c5427ba8f9a268e2cf0b5b
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ULK1 phosphorylates Exo70 to suppress breast cancer metastasis

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