Crystal structure and receptor-interacting residues of MYDGF — a protein mediating ischemic tissue repair

Myeloid-derived growth factor (MYDGF) is an angiogenic growth factor with therapeutic potential for ischemic tissue repair and the receptor is still unknown. Here the authors present the crystal structure of human MYDGF and identify its functional epitope through mutagenesis studies.

Guardado en:

Detalles Bibliográficos
Autores principales:	Rebecca Ebenhoch, Abbas Akhdar, Marc R. Reboll, Mortimer Korf-Klingebiel, Priyanka Gupta, Julie Armstrong, Yining Huang, Lee Frego, Irina Rybina, John Miglietta, Anton Pekcec, Kai C. Wollert, Herbert Nar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7aa1821abf454c21a63dba52daa89da7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7aa1821abf454c21a63dba52daa89da7
record_format	dspace
spelling	oai:doaj.org-article:7aa1821abf454c21a63dba52daa89da72021-12-02T17:01:50ZCrystal structure and receptor-interacting residues of MYDGF — a protein mediating ischemic tissue repair10.1038/s41467-019-13343-72041-1723https://doaj.org/article/7aa1821abf454c21a63dba52daa89da72019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13343-7https://doaj.org/toc/2041-1723Myeloid-derived growth factor (MYDGF) is an angiogenic growth factor with therapeutic potential for ischemic tissue repair and the receptor is still unknown. Here the authors present the crystal structure of human MYDGF and identify its functional epitope through mutagenesis studies.Rebecca EbenhochAbbas AkhdarMarc R. RebollMortimer Korf-KlingebielPriyanka GuptaJulie ArmstrongYining HuangLee FregoIrina RybinaJohn MigliettaAnton PekcecKai C. WollertHerbert NarNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca Ebenhoch Abbas Akhdar Marc R. Reboll Mortimer Korf-Klingebiel Priyanka Gupta Julie Armstrong Yining Huang Lee Frego Irina Rybina John Miglietta Anton Pekcec Kai C. Wollert Herbert Nar Crystal structure and receptor-interacting residues of MYDGF — a protein mediating ischemic tissue repair
description	Myeloid-derived growth factor (MYDGF) is an angiogenic growth factor with therapeutic potential for ischemic tissue repair and the receptor is still unknown. Here the authors present the crystal structure of human MYDGF and identify its functional epitope through mutagenesis studies.
format	article
author	Rebecca Ebenhoch Abbas Akhdar Marc R. Reboll Mortimer Korf-Klingebiel Priyanka Gupta Julie Armstrong Yining Huang Lee Frego Irina Rybina John Miglietta Anton Pekcec Kai C. Wollert Herbert Nar
author_facet	Rebecca Ebenhoch Abbas Akhdar Marc R. Reboll Mortimer Korf-Klingebiel Priyanka Gupta Julie Armstrong Yining Huang Lee Frego Irina Rybina John Miglietta Anton Pekcec Kai C. Wollert Herbert Nar
author_sort	Rebecca Ebenhoch
title	Crystal structure and receptor-interacting residues of MYDGF — a protein mediating ischemic tissue repair
title_short	Crystal structure and receptor-interacting residues of MYDGF — a protein mediating ischemic tissue repair
title_full	Crystal structure and receptor-interacting residues of MYDGF — a protein mediating ischemic tissue repair
title_fullStr	Crystal structure and receptor-interacting residues of MYDGF — a protein mediating ischemic tissue repair
title_full_unstemmed	Crystal structure and receptor-interacting residues of MYDGF — a protein mediating ischemic tissue repair
title_sort	crystal structure and receptor-interacting residues of mydgf — a protein mediating ischemic tissue repair
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7aa1821abf454c21a63dba52daa89da7
work_keys_str_mv	AT rebeccaebenhoch crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT abbasakhdar crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT marcrreboll crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT mortimerkorfklingebiel crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT priyankagupta crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT juliearmstrong crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT yininghuang crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT leefrego crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT irinarybina crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT johnmiglietta crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT antonpekcec crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT kaicwollert crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair AT herbertnar crystalstructureandreceptorinteractingresiduesofmydgfaproteinmediatingischemictissuerepair
_version_	1718382035857309696

Crystal structure and receptor-interacting residues of MYDGF — a protein mediating ischemic tissue repair

Ejemplares similares