Streamlined asymmetric α-difunctionalization of ynones

Chiral ynones with an α-quaternary carbon are attractive synthetic building blocks for natural and pharmaceutical products. Here, the authors report an asymmetric α-difunctionalization of simple ynones, involving a gold-catalyzed step and yielding enantioenriched fluorinated quaternary stereocentres...

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Autores principales:	Siyu Peng, Zhaofeng Wang, Linxing Zhang, Xinhao Zhang, Yong Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7aae27bc9ca542bbaead7d09124b167e
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spelling	oai:doaj.org-article:7aae27bc9ca542bbaead7d09124b167e2021-12-02T16:49:22ZStreamlined asymmetric α-difunctionalization of ynones10.1038/s41467-017-02801-92041-1723https://doaj.org/article/7aae27bc9ca542bbaead7d09124b167e2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02801-9https://doaj.org/toc/2041-1723Chiral ynones with an α-quaternary carbon are attractive synthetic building blocks for natural and pharmaceutical products. Here, the authors report an asymmetric α-difunctionalization of simple ynones, involving a gold-catalyzed step and yielding enantioenriched fluorinated quaternary stereocentres.Siyu PengZhaofeng WangLinxing ZhangXinhao ZhangYong HuangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siyu Peng Zhaofeng Wang Linxing Zhang Xinhao Zhang Yong Huang Streamlined asymmetric α-difunctionalization of ynones
description	Chiral ynones with an α-quaternary carbon are attractive synthetic building blocks for natural and pharmaceutical products. Here, the authors report an asymmetric α-difunctionalization of simple ynones, involving a gold-catalyzed step and yielding enantioenriched fluorinated quaternary stereocentres.
format	article
author	Siyu Peng Zhaofeng Wang Linxing Zhang Xinhao Zhang Yong Huang
author_facet	Siyu Peng Zhaofeng Wang Linxing Zhang Xinhao Zhang Yong Huang
author_sort	Siyu Peng
title	Streamlined asymmetric α-difunctionalization of ynones
title_short	Streamlined asymmetric α-difunctionalization of ynones
title_full	Streamlined asymmetric α-difunctionalization of ynones
title_fullStr	Streamlined asymmetric α-difunctionalization of ynones
title_full_unstemmed	Streamlined asymmetric α-difunctionalization of ynones
title_sort	streamlined asymmetric α-difunctionalization of ynones
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7aae27bc9ca542bbaead7d09124b167e
work_keys_str_mv	AT siyupeng streamlinedasymmetricadifunctionalizationofynones AT zhaofengwang streamlinedasymmetricadifunctionalizationofynones AT linxingzhang streamlinedasymmetricadifunctionalizationofynones AT xinhaozhang streamlinedasymmetricadifunctionalizationofynones AT yonghuang streamlinedasymmetricadifunctionalizationofynones
_version_	1718383341767491584

Streamlined asymmetric α-difunctionalization of ynones

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