Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma

Abstract Knowledge of 1p/19q-codeletion and IDH1/2 mutational status is necessary to interpret any investigational study of diffuse gliomas in the modern era. While DNA sequencing is the gold standard for determining IDH mutational status, genome-wide methylation arrays and gene expression profiling...

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Autores principales: Nicholas Nuechterlein, Linda G. Shapiro, Eric C. Holland, Patrick J. Cimino
Formato: article
Lenguaje:EN
Publicado: BMC 2021
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IDH
Acceso en línea:https://doaj.org/article/7ae1cad55a3b4fa3835686acc7e09a84
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