A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

Alterations to the androgen receptor (AR) signalling axis and cellular metabolism are hallmarks of prostate cancer. This study provides insight into both hallmarks by uncovering a novel link between AR and the pentose phosphate pathway (PPP). Specifically, we identify 6-phosphogluoconate dehydrogena...

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Bibliographic Details
Main Authors: Joanna L Gillis, Josephine A Hinneh, Natalie K Ryan, Swati Irani, Max Moldovan, Lake-Ee Quek, Raj K Shrestha, Adrienne R Hanson, Jianling Xie, Andrew J Hoy, Jeff Holst, Margaret M Centenera, Ian G Mills, David J Lynn, Luke A Selth, Lisa M Butler
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
pentose phosphate pathway
prostate cancer
androgen receptor
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/7b041890c6d2431cb95c6683b6ee5211
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https://doaj.org/article/7b041890c6d2431cb95c6683b6ee5211

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