Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence

Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence

ABSTRACT There is an urgent need to develop novel antifungals to tackle the threat fungal pathogens pose to human health. Here, we have performed a comprehensive characterization and validation of the promising target methionine synthase (MetH). We show that in Aspergillus fumigatus the absence of t...

Full description

Saved in:
Bibliographic Details
Main Authors: Jennifer Scott, Monica Sueiro-Olivares, Benjamin P. Thornton, Rebecca A. Owens, Howbeer Muhamadali, Rachael Fortune-Grant, Darren Thomson, Riba Thomas, Katherine Hollywood, Sean Doyle, Royston Goodacre, Lydia Tabernero, Elaine Bignell, Jorge Amich
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
antifungal target
Aspergillus fumigatus
doxycycline
established infection
fungal virulence
methionine synthase
Microbiology
QR1-502
Online Access:https://doaj.org/article/7b12c5539a3341cab8baab5ee44d445b
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/7b12c5539a3341cab8baab5ee44d445b

Similar Items