High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites

High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites

Abstract Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential functions in all of the major life cycle developmental stages. An imidazopyridine PKG inhibitor scaffold...

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Autores principales: Maria Penzo, Laura de las Heras-Dueña, Lydia Mata-Cantero, Beatriz Diaz-Hernandez, Maria-Jesus Vazquez-Muñiz, Sonja Ghidelli-Disse, Gerard Drewes, Elena Fernandez-Alvaro, David A. Baker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/7b1853796974419994e20d37569169f5
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https://doaj.org/article/7b1853796974419994e20d37569169f5

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