Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis

GM-CSF has been implicated in Mycobacterium tuberculosis (Mtb) host control. Here, the authors show that activation of GM-CSF discriminates Mtb-restrictive from -permissive macrophages while co-infection with HIV disrupts GM-CSF-mediated signaling, rendering macrophages susceptible to bacterial infe...

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Autores principales: Bryan D. Bryson, Tracy R. Rosebrock, Fikadu G. Tafesse, Christopher Y. Itoh, Armel Nibasumba, Gregory H. Babunovic, Bjorn Corleis, Constance Martin, Caroline Keegan, Priscila Andrade, Susan Realegeno, Douglas Kwon, Robert L. Modlin, Sarah M. Fortune
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7b1cd08cca8c4de48969bd62ffdea2d7
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