Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis

GM-CSF has been implicated in Mycobacterium tuberculosis (Mtb) host control. Here, the authors show that activation of GM-CSF discriminates Mtb-restrictive from -permissive macrophages while co-infection with HIV disrupts GM-CSF-mediated signaling, rendering macrophages susceptible to bacterial infe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bryan D. Bryson, Tracy R. Rosebrock, Fikadu G. Tafesse, Christopher Y. Itoh, Armel Nibasumba, Gregory H. Babunovic, Bjorn Corleis, Constance Martin, Caroline Keegan, Priscila Andrade, Susan Realegeno, Douglas Kwon, Robert L. Modlin, Sarah M. Fortune
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b1cd08cca8c4de48969bd62ffdea2d7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7b1cd08cca8c4de48969bd62ffdea2d7
record_format	dspace
spelling	oai:doaj.org-article:7b1cd08cca8c4de48969bd62ffdea2d72021-12-02T14:39:42ZHeterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis10.1038/s41467-019-10065-82041-1723https://doaj.org/article/7b1cd08cca8c4de48969bd62ffdea2d72019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10065-8https://doaj.org/toc/2041-1723GM-CSF has been implicated in Mycobacterium tuberculosis (Mtb) host control. Here, the authors show that activation of GM-CSF discriminates Mtb-restrictive from -permissive macrophages while co-infection with HIV disrupts GM-CSF-mediated signaling, rendering macrophages susceptible to bacterial infection.Bryan D. BrysonTracy R. RosebrockFikadu G. TafesseChristopher Y. ItohArmel NibasumbaGregory H. BabunovicBjorn CorleisConstance MartinCaroline KeeganPriscila AndradeSusan RealegenoDouglas KwonRobert L. ModlinSarah M. FortuneNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bryan D. Bryson Tracy R. Rosebrock Fikadu G. Tafesse Christopher Y. Itoh Armel Nibasumba Gregory H. Babunovic Bjorn Corleis Constance Martin Caroline Keegan Priscila Andrade Susan Realegeno Douglas Kwon Robert L. Modlin Sarah M. Fortune Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis
description	GM-CSF has been implicated in Mycobacterium tuberculosis (Mtb) host control. Here, the authors show that activation of GM-CSF discriminates Mtb-restrictive from -permissive macrophages while co-infection with HIV disrupts GM-CSF-mediated signaling, rendering macrophages susceptible to bacterial infection.
format	article
author	Bryan D. Bryson Tracy R. Rosebrock Fikadu G. Tafesse Christopher Y. Itoh Armel Nibasumba Gregory H. Babunovic Bjorn Corleis Constance Martin Caroline Keegan Priscila Andrade Susan Realegeno Douglas Kwon Robert L. Modlin Sarah M. Fortune
author_facet	Bryan D. Bryson Tracy R. Rosebrock Fikadu G. Tafesse Christopher Y. Itoh Armel Nibasumba Gregory H. Babunovic Bjorn Corleis Constance Martin Caroline Keegan Priscila Andrade Susan Realegeno Douglas Kwon Robert L. Modlin Sarah M. Fortune
author_sort	Bryan D. Bryson
title	Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis
title_short	Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis
title_full	Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis
title_fullStr	Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis
title_full_unstemmed	Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis
title_sort	heterogeneous gm-csf signaling in macrophages is associated with control of mycobacterium tuberculosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7b1cd08cca8c4de48969bd62ffdea2d7
work_keys_str_mv	AT bryandbryson heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT tracyrrosebrock heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT fikadugtafesse heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT christopheryitoh heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT armelnibasumba heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT gregoryhbabunovic heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT bjorncorleis heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT constancemartin heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT carolinekeegan heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT priscilaandrade heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT susanrealegeno heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT douglaskwon heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT robertlmodlin heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis AT sarahmfortune heterogeneousgmcsfsignalinginmacrophagesisassociatedwithcontrolofmycobacteriumtuberculosis
_version_	1718390539983781888

Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis

Ejemplares similares