Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function

Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function

Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to treat detrimental inflammatory conditions after transplantation and during autoimmune disease. To reach sufficient cell yield for treatment, ex vivo isolated autologous or allogenic Tregs need to be expanded exte...

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Autores principales: Kristy Ou, Dania Hamo, Anne Schulze, Andy Roemhild, Daniel Kaiser, Gilles Gasparoni, Abdulrahman Salhab, Ghazaleh Zarrinrad, Leila Amini, Stephan Schlickeiser, Mathias Streitz, Jörn Walter, Hans-Dieter Volk, Michael Schmueck-Henneresse, Petra Reinke, Julia K. Polansky
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
regulatory T cells
advanced therapy medicinal products
DNA methylation
biomarker
adoptive cell therapy
good manufacturing practice
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/7b260d54dd1e425b9ebf78e959997007
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https://doaj.org/article/7b260d54dd1e425b9ebf78e959997007

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