G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old

Abstract Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and includ...

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Autores principales:	Qiukui Hao, Yuting Wang, Xiang Ding, Biao Dong, Ming Yang, Birong Dong, Yuquan Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b283425b40a43b4b26be68133de5933
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spelling	oai:doaj.org-article:7b283425b40a43b4b26be68133de59332021-12-02T16:08:25ZG-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old10.1038/s41598-018-25040-42045-2322https://doaj.org/article/7b283425b40a43b4b26be68133de59332018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25040-4https://doaj.org/toc/2045-2322Abstract Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a cohort of Chinese nonagenarians and centenarians for our study. This study is part of a cross-sectional study and secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study, which was conducted in Southwest China. Community-dwelling Chinese residents aged 90 years or older were included in this study. Frailty was determined using the FRAIL scale as proposed by the International Association of Nutrition and Aging. On the FRAIL scale, frailty was defined by a score of ≥3. G-395A (rs1207568) genotyping of the promoter region of the KL gene was performed using TaqMan allelic discrimination assay. A total of 632 participants (68.4% females; mean age: 93.5 ± 3.2 years) were included. KL G-395A polymorphism genotype frequencies were 1.7% AA, 25.6% GA, and 72.7% GG in our sample. GG genotype frequencies for the frailty and control groups were 83.6% and 71.2%, respectively. Frailty prevalence was significantly lower in the GA+AA group when compared to the GG genotype group (6.9% vs. 13.3%, P = 0.026). In addition, subjects with a GA+AA genotype had a significantly lower risk of frailty (odds ratio (OR): 0.47, 95% confidence interval (CI) 0.23 to 0.97, P = 0.040) compared to the GG genotype after adjusting for age, gender, education level, smoking, alcohol consumption, exercise, body mass index (BMI), cognitive impairment, and other potential factors. KL-395A allele carrying genotypes (GA and AA) is associated with a lower risk of frailty relative to GG genotypes in a sample of Chinese nonagenarians and centenarians.Qiukui HaoYuting WangXiang DingBiao DongMing YangBirong DongYuquan WeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiukui Hao Yuting Wang Xiang Ding Biao Dong Ming Yang Birong Dong Yuquan Wei G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
description	Abstract Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a cohort of Chinese nonagenarians and centenarians for our study. This study is part of a cross-sectional study and secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study, which was conducted in Southwest China. Community-dwelling Chinese residents aged 90 years or older were included in this study. Frailty was determined using the FRAIL scale as proposed by the International Association of Nutrition and Aging. On the FRAIL scale, frailty was defined by a score of ≥3. G-395A (rs1207568) genotyping of the promoter region of the KL gene was performed using TaqMan allelic discrimination assay. A total of 632 participants (68.4% females; mean age: 93.5 ± 3.2 years) were included. KL G-395A polymorphism genotype frequencies were 1.7% AA, 25.6% GA, and 72.7% GG in our sample. GG genotype frequencies for the frailty and control groups were 83.6% and 71.2%, respectively. Frailty prevalence was significantly lower in the GA+AA group when compared to the GG genotype group (6.9% vs. 13.3%, P = 0.026). In addition, subjects with a GA+AA genotype had a significantly lower risk of frailty (odds ratio (OR): 0.47, 95% confidence interval (CI) 0.23 to 0.97, P = 0.040) compared to the GG genotype after adjusting for age, gender, education level, smoking, alcohol consumption, exercise, body mass index (BMI), cognitive impairment, and other potential factors. KL-395A allele carrying genotypes (GA and AA) is associated with a lower risk of frailty relative to GG genotypes in a sample of Chinese nonagenarians and centenarians.
format	article
author	Qiukui Hao Yuting Wang Xiang Ding Biao Dong Ming Yang Birong Dong Yuquan Wei
author_facet	Qiukui Hao Yuting Wang Xiang Ding Biao Dong Ming Yang Birong Dong Yuquan Wei
author_sort	Qiukui Hao
title	G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
title_short	G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
title_full	G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
title_fullStr	G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
title_full_unstemmed	G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
title_sort	g-395a polymorphism in the promoter region of the klotho gene associates with frailty among the oldest-old
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7b283425b40a43b4b26be68133de5933
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G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old

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