G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old

Abstract Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and includ...

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Bibliographic Details
Main Authors: Qiukui Hao, Yuting Wang, Xiang Ding, Biao Dong, Ming Yang, Birong Dong, Yuquan Wei
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
R
Q
Online Access:https://doaj.org/article/7b283425b40a43b4b26be68133de5933
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