Structural and functional insights into esterase-mediated macrolide resistance

Erythromycin esterases (Eres) cleave the macrolactone ring of macrolides, a class of widely used antibiotics. Structures of EreC, in silico flexible docking studies and previous mutagenesis data lead to the proposal of a detailed catalytic mechanism for the Ere family of enzymes.

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Autores principales: Michał Zieliński, Jaeok Park, Barry Sleno, Albert M. Berghuis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7b2d872b0cc04ef1b3ff7eb82c9ff6ed
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