Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

The blood-brain barrier often limits effective delivery of treatments for glioblastoma . In this study, the authors develop transferrin-functionalized nanoparticles able to traverse the intact blood-brain barrier and deliver combination temozolomide and bromodomain inhibitor therapy to glioma-bear...

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Autores principales:	Fred C. Lam, Stephen W. Morton, Jeffrey Wyckoff, Tu-Lan Vu Han, Mun Kyung Hwang, Amanda Maffa, Elena Balkanska-Sinclair, Michael B Yaffe, Scott R Floyd, Paula T Hammond
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b4a074c2e9340cbb338535cafd8e632
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spelling	oai:doaj.org-article:7b4a074c2e9340cbb338535cafd8e6322021-12-02T16:49:53ZEnhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles10.1038/s41467-018-04315-42041-1723https://doaj.org/article/7b4a074c2e9340cbb338535cafd8e6322018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04315-4https://doaj.org/toc/2041-1723The blood-brain barrier often limits effective delivery of treatments for glioblastoma . In this study, the authors develop transferrin-functionalized nanoparticles able to traverse the intact blood-brain barrier and deliver combination temozolomide and bromodomain inhibitor therapy to glioma-bearing mice.Fred C. LamStephen W. MortonJeffrey WyckoffTu-Lan Vu HanMun Kyung HwangAmanda MaffaElena Balkanska-SinclairMichael B YaffeScott R FloydPaula T HammondNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fred C. Lam Stephen W. Morton Jeffrey Wyckoff Tu-Lan Vu Han Mun Kyung Hwang Amanda Maffa Elena Balkanska-Sinclair Michael B Yaffe Scott R Floyd Paula T Hammond Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles
description	The blood-brain barrier often limits effective delivery of treatments for glioblastoma . In this study, the authors develop transferrin-functionalized nanoparticles able to traverse the intact blood-brain barrier and deliver combination temozolomide and bromodomain inhibitor therapy to glioma-bearing mice.
format	article
author	Fred C. Lam Stephen W. Morton Jeffrey Wyckoff Tu-Lan Vu Han Mun Kyung Hwang Amanda Maffa Elena Balkanska-Sinclair Michael B Yaffe Scott R Floyd Paula T Hammond
author_facet	Fred C. Lam Stephen W. Morton Jeffrey Wyckoff Tu-Lan Vu Han Mun Kyung Hwang Amanda Maffa Elena Balkanska-Sinclair Michael B Yaffe Scott R Floyd Paula T Hammond
author_sort	Fred C. Lam
title	Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles
title_short	Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles
title_full	Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles
title_fullStr	Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles
title_full_unstemmed	Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles
title_sort	enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7b4a074c2e9340cbb338535cafd8e632
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Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

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