NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.

Mammalian methionine adenosyltransferase II (MAT II) is the only hetero-oligomer in this family of enzymes that synthesize S-adenosylmethionine using methionine and ATP as substrates. Binding of regulatory β subunits and catalytic α2 dimers is known to increase the affinity for methionine, although...

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Auteurs principaux: Beatriz González, Francisco Garrido, Rebeca Ortega, Marta Martínez-Júlvez, Ainhoa Revilla-Guarinos, Yolanda Pérez-Pertejo, Adrián Velázquez-Campoy, Julia Sanz-Aparicio, María A Pajares
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
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Accès en ligne:https://doaj.org/article/7b4b669595844ce0a855757355bdd4c1
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