The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells
How the REGγ-proteasome pathway is regulated during the cell cycle or genotoxic insults remains unclear. Here, the authors show that NIP30 acts as a molecular switch to regulate the REGγ-proteasome activity and may provide an approach to combat drug-resistant tumours lacking functional p53.
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Nature Portfolio
2020
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oai:doaj.org-article:7b5a15238e124a499bbec73fb760c7252021-12-02T14:53:44ZThe REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells10.1038/s41467-020-17667-72041-1723https://doaj.org/article/7b5a15238e124a499bbec73fb760c7252020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17667-7https://doaj.org/toc/2041-1723How the REGγ-proteasome pathway is regulated during the cell cycle or genotoxic insults remains unclear. Here, the authors show that NIP30 acts as a molecular switch to regulate the REGγ-proteasome activity and may provide an approach to combat drug-resistant tumours lacking functional p53.Xiao GaoQingwei WangYing WangJiang LiuShuang LiuJian LiuXingli ZhouLi ZhouHui ChenLinian PanJiwei ChenDa WangQing ZhangShihui ShenYu XiaoZhipeng WuYiyun ChengGeng ChenSyeda KubraJun QinLan HuangPei ZhangChuangui WangRobb E. MosesDavid M. LonardBert W. O’ MalleyFuad FaresBianhong ZhangXiaotao LiLei LiJianru XiaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
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Science Q |
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Science Q Xiao Gao Qingwei Wang Ying Wang Jiang Liu Shuang Liu Jian Liu Xingli Zhou Li Zhou Hui Chen Linian Pan Jiwei Chen Da Wang Qing Zhang Shihui Shen Yu Xiao Zhipeng Wu Yiyun Cheng Geng Chen Syeda Kubra Jun Qin Lan Huang Pei Zhang Chuangui Wang Robb E. Moses David M. Lonard Bert W. O’ Malley Fuad Fares Bianhong Zhang Xiaotao Li Lei Li Jianru Xiao The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells |
| description |
How the REGγ-proteasome pathway is regulated during the cell cycle or genotoxic insults remains unclear. Here, the authors show that NIP30 acts as a molecular switch to regulate the REGγ-proteasome activity and may provide an approach to combat drug-resistant tumours lacking functional p53. |
| format |
article |
| author |
Xiao Gao Qingwei Wang Ying Wang Jiang Liu Shuang Liu Jian Liu Xingli Zhou Li Zhou Hui Chen Linian Pan Jiwei Chen Da Wang Qing Zhang Shihui Shen Yu Xiao Zhipeng Wu Yiyun Cheng Geng Chen Syeda Kubra Jun Qin Lan Huang Pei Zhang Chuangui Wang Robb E. Moses David M. Lonard Bert W. O’ Malley Fuad Fares Bianhong Zhang Xiaotao Li Lei Li Jianru Xiao |
| author_facet |
Xiao Gao Qingwei Wang Ying Wang Jiang Liu Shuang Liu Jian Liu Xingli Zhou Li Zhou Hui Chen Linian Pan Jiwei Chen Da Wang Qing Zhang Shihui Shen Yu Xiao Zhipeng Wu Yiyun Cheng Geng Chen Syeda Kubra Jun Qin Lan Huang Pei Zhang Chuangui Wang Robb E. Moses David M. Lonard Bert W. O’ Malley Fuad Fares Bianhong Zhang Xiaotao Li Lei Li Jianru Xiao |
| author_sort |
Xiao Gao |
| title |
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells |
| title_short |
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells |
| title_full |
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells |
| title_fullStr |
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells |
| title_full_unstemmed |
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells |
| title_sort |
regγ inhibitor nip30 increases sensitivity to chemotherapy in p53-deficient tumor cells |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/7b5a15238e124a499bbec73fb760c725 |
| work_keys_str_mv |
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