The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells

The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells

How the REGγ-proteasome pathway is regulated during the cell cycle or genotoxic insults remains unclear. Here, the authors show that NIP30 acts as a molecular switch to regulate the REGγ-proteasome activity and may provide an approach to combat drug-resistant tumours lacking functional p53.

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Detalles Bibliográficos
Autores principales: Xiao Gao, Qingwei Wang, Ying Wang, Jiang Liu, Shuang Liu, Jian Liu, Xingli Zhou, Li Zhou, Hui Chen, Linian Pan, Jiwei Chen, Da Wang, Qing Zhang, Shihui Shen, Yu Xiao, Zhipeng Wu, Yiyun Cheng, Geng Chen, Syeda Kubra, Jun Qin, Lan Huang, Pei Zhang, Chuangui Wang, Robb E. Moses, David M. Lonard, Bert W. O’ Malley, Fuad Fares, Bianhong Zhang, Xiaotao Li, Lei Li, Jianru Xiao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/7b5a15238e124a499bbec73fb760c725
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