Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media

Abstract Chronic suppurative otitis media (CSOM) is a widespread, debilitating problem with poorly understood immunology. Here, we assess the host response to middle ear infection over the course of a month post-infection in a mouse model of CSOM and in human subjects with the disease. Using multipa...

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Bibliographic Details
Main Authors: K. M. Khomtchouk, L. I. Joseph, B. B. Khomtchouk, A. Kouhi, S. Massa, A. Xia, I. Koliesnik, D. Pletzer, P. L. Bollyky, P. L. Santa Maria
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/7b834c89fd354cdaa19d65fb3bc5042d
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