Increase in the Antioxidant and Anti-Inflammatory Activity of <i>Euterpe oleracea</i> Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin
Reactive oxygen species (ROS) are aerobic products generated during cellular respiration, but in the case of oxidative stress, they become key factors in the development of inflammatory processes and chronic diseases such as diabetes and rheumatoid arthritis. In this work, <i>Euterpe oleracea&...
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oai:doaj.org-article:7ba11a0d55374150bdb414b053ab73262021-11-11T16:59:03ZIncrease in the Antioxidant and Anti-Inflammatory Activity of <i>Euterpe oleracea</i> Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin10.3390/ijms2221115241422-00671661-6596https://doaj.org/article/7ba11a0d55374150bdb414b053ab73262021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11524https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Reactive oxygen species (ROS) are aerobic products generated during cellular respiration, but in the case of oxidative stress, they become key factors in the development of inflammatory processes and chronic diseases such as diabetes and rheumatoid arthritis. In this work, <i>Euterpe oleracea</i> oil (EOO), as well as the complexes produced by slurry (S) and kneading (K), were analyzed for antioxidant capacity in vitro, while only the β-cyclodextrin complex obtained by kneading (EOO-βCD-K), which showed better complexation, was selected for anti-inflammatory assays in vivo. In the scavenging activity of OH·, the hydroxypropyl-β-cyclodextrin complex obtained by kneading (EOO-HPβCD-K) exhibited an activity 437% higher than the pure oil. In the paw edema assay, EOO-βCD-K reduced edema by 200% and myeloperoxidase (MPO) activity by 112%. In an air pouch model, this treatment showed a reduction in leukocyte, MPO, and Interleukin-1β (IL-1β) levels; meanwhile those of glutathione and IL-10 were increased, demonstrating its ability to potentiate the anti-inflammatory effect of EOO.Thalita Sévia Soares de Almeida MagalhãesPollyana Cristina de Oliveira MacedoÉrika Cibely Pinheiro da CostaEmanuella de Aragão TavaresValéria Costa da SilvaGerlane Coelho Bernardo GuerraJoquebede Rodrigues PereiraTelma Maria de Araújo Moura LemosMarília Medeiros Fernandes de NegreirosHugo Alexandre de Oliveira RochaAttilio ConvertiÁdley Antonini Neves de LimaMDPI AGarticle<i>Euterpe oleraceae</i>inclusion complexesantioxidantanti-inflammatoryBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11524, p 11524 (2021) |
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| topic |
<i>Euterpe oleraceae</i> inclusion complexes antioxidant anti-inflammatory Biology (General) QH301-705.5 Chemistry QD1-999 |
| spellingShingle |
<i>Euterpe oleraceae</i> inclusion complexes antioxidant anti-inflammatory Biology (General) QH301-705.5 Chemistry QD1-999 Thalita Sévia Soares de Almeida Magalhães Pollyana Cristina de Oliveira Macedo Érika Cibely Pinheiro da Costa Emanuella de Aragão Tavares Valéria Costa da Silva Gerlane Coelho Bernardo Guerra Joquebede Rodrigues Pereira Telma Maria de Araújo Moura Lemos Marília Medeiros Fernandes de Negreiros Hugo Alexandre de Oliveira Rocha Attilio Converti Ádley Antonini Neves de Lima Increase in the Antioxidant and Anti-Inflammatory Activity of <i>Euterpe oleracea</i> Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin |
| description |
Reactive oxygen species (ROS) are aerobic products generated during cellular respiration, but in the case of oxidative stress, they become key factors in the development of inflammatory processes and chronic diseases such as diabetes and rheumatoid arthritis. In this work, <i>Euterpe oleracea</i> oil (EOO), as well as the complexes produced by slurry (S) and kneading (K), were analyzed for antioxidant capacity in vitro, while only the β-cyclodextrin complex obtained by kneading (EOO-βCD-K), which showed better complexation, was selected for anti-inflammatory assays in vivo. In the scavenging activity of OH·, the hydroxypropyl-β-cyclodextrin complex obtained by kneading (EOO-HPβCD-K) exhibited an activity 437% higher than the pure oil. In the paw edema assay, EOO-βCD-K reduced edema by 200% and myeloperoxidase (MPO) activity by 112%. In an air pouch model, this treatment showed a reduction in leukocyte, MPO, and Interleukin-1β (IL-1β) levels; meanwhile those of glutathione and IL-10 were increased, demonstrating its ability to potentiate the anti-inflammatory effect of EOO. |
| format |
article |
| author |
Thalita Sévia Soares de Almeida Magalhães Pollyana Cristina de Oliveira Macedo Érika Cibely Pinheiro da Costa Emanuella de Aragão Tavares Valéria Costa da Silva Gerlane Coelho Bernardo Guerra Joquebede Rodrigues Pereira Telma Maria de Araújo Moura Lemos Marília Medeiros Fernandes de Negreiros Hugo Alexandre de Oliveira Rocha Attilio Converti Ádley Antonini Neves de Lima |
| author_facet |
Thalita Sévia Soares de Almeida Magalhães Pollyana Cristina de Oliveira Macedo Érika Cibely Pinheiro da Costa Emanuella de Aragão Tavares Valéria Costa da Silva Gerlane Coelho Bernardo Guerra Joquebede Rodrigues Pereira Telma Maria de Araújo Moura Lemos Marília Medeiros Fernandes de Negreiros Hugo Alexandre de Oliveira Rocha Attilio Converti Ádley Antonini Neves de Lima |
| author_sort |
Thalita Sévia Soares de Almeida Magalhães |
| title |
Increase in the Antioxidant and Anti-Inflammatory Activity of <i>Euterpe oleracea</i> Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin |
| title_short |
Increase in the Antioxidant and Anti-Inflammatory Activity of <i>Euterpe oleracea</i> Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin |
| title_full |
Increase in the Antioxidant and Anti-Inflammatory Activity of <i>Euterpe oleracea</i> Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin |
| title_fullStr |
Increase in the Antioxidant and Anti-Inflammatory Activity of <i>Euterpe oleracea</i> Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin |
| title_full_unstemmed |
Increase in the Antioxidant and Anti-Inflammatory Activity of <i>Euterpe oleracea</i> Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin |
| title_sort |
increase in the antioxidant and anti-inflammatory activity of <i>euterpe oleracea</i> martius oil complexed in β-cyclodextrin and hydroxypropyl-β-cyclodextrin |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/7ba11a0d55374150bdb414b053ab7326 |
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