Computer-aided design, synthesis, and characterization of molecular hybrids of dihydropyrazoles, aminopyrimidines, and thiazolidin-4-ones as potential inhibitors of the penicillin-binding protein 3 (PBP-3) of Escherichia coli
A computer-assisted approach was used to model and study privileged heterocyclic scaffolds containing dihydropyrazole, pyrimidin-2-amine, and thiazolidin-4-one moieties (hybrid pharmacophores) to obtain novel and promising antimicrobial prototype molecules. Main bioavailability descriptors were d...
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| Formato: | article |
| Lenguaje: | EN ES |
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Pontificia Universidad Javeriana
2021
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| Acceso en línea: | https://doaj.org/article/7bae2324ad9548a98c2a4823fc69d2b4 |
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