Transcriptomic profiling of whole blood in 22q11.2 reciprocal copy number variants reveals that cell proportion highly impacts gene expression

Transcriptomic profiling of whole blood in 22q11.2 reciprocal copy number variants reveals that cell proportion highly impacts gene expression

22q11.2 reciprocal copy number variants (CNVs) offer a powerful quasi-experimental “reverse-genetics” paradigm to elucidate how gene dosage (i.e., deletions and duplications) disrupts the transcriptome to cause further downstream effects. Clinical profiles of 22q11.2 CNV carriers indicate that disru...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Amy Lin, Jennifer K. Forsyth, Gil D. Hoftman, Leila Kushan-Wells, Maria Jalbrzikowski, Deepika Dokuru, Giovanni Coppola, Ania Fiksinski, Janneke Zinkstok, Jacob Vorstman, Daniel Nachun, Carrie E. Bearden
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
22q11.2
Copy number variation
Transcriptome
Differential expression
Whole blood
Cell type composition
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Acceso en línea:https://doaj.org/article/7bbf0d5c64de4d89987d58b825e1a27b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/7bbf0d5c64de4d89987d58b825e1a27b

Ejemplares similares