Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures

Gaia Andreoletti et al. leverage cell-sorted RNA-seq data and machine learning to investigate gene expression patterns in immune cell subtypes purified from Asian and White patients with a medical diagnosis of systemic lupus erythematosus (SLE). They report distinct clinical subtypes of SLE and iden...

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Autores principales:	Gaia Andreoletti, Cristina M. Lanata, Laura Trupin, Ishan Paranjpe, Tia S. Jain, Joanne Nititham, Kimberly E. Taylor, Alexis J. Combes, Lenka Maliskova, Chun Jimmie Ye, Patricia Katz, Maria Dall’Era, Jinoos Yazdany, Lindsey A. Criswell, Marina Sirota
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7bed769c8e6e4805aebc706b9462c06e
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spelling	oai:doaj.org-article:7bed769c8e6e4805aebc706b9462c06e2021-12-02T17:32:55ZTranscriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures10.1038/s42003-021-02000-92399-3642https://doaj.org/article/7bed769c8e6e4805aebc706b9462c06e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02000-9https://doaj.org/toc/2399-3642Gaia Andreoletti et al. leverage cell-sorted RNA-seq data and machine learning to investigate gene expression patterns in immune cell subtypes purified from Asian and White patients with a medical diagnosis of systemic lupus erythematosus (SLE). They report distinct clinical subtypes of SLE and identify ethnicity- and disease-specific gene clusters, potentially contributing toward the future development of personalized therapeutic strategies for patients with SLE.Gaia AndreolettiCristina M. LanataLaura TrupinIshan ParanjpeTia S. JainJoanne NitithamKimberly E. TaylorAlexis J. CombesLenka MaliskovaChun Jimmie YePatricia KatzMaria Dall’EraJinoos YazdanyLindsey A. CriswellMarina SirotaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Gaia Andreoletti Cristina M. Lanata Laura Trupin Ishan Paranjpe Tia S. Jain Joanne Nititham Kimberly E. Taylor Alexis J. Combes Lenka Maliskova Chun Jimmie Ye Patricia Katz Maria Dall’Era Jinoos Yazdany Lindsey A. Criswell Marina Sirota Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures
description	Gaia Andreoletti et al. leverage cell-sorted RNA-seq data and machine learning to investigate gene expression patterns in immune cell subtypes purified from Asian and White patients with a medical diagnosis of systemic lupus erythematosus (SLE). They report distinct clinical subtypes of SLE and identify ethnicity- and disease-specific gene clusters, potentially contributing toward the future development of personalized therapeutic strategies for patients with SLE.
format	article
author	Gaia Andreoletti Cristina M. Lanata Laura Trupin Ishan Paranjpe Tia S. Jain Joanne Nititham Kimberly E. Taylor Alexis J. Combes Lenka Maliskova Chun Jimmie Ye Patricia Katz Maria Dall’Era Jinoos Yazdany Lindsey A. Criswell Marina Sirota
author_facet	Gaia Andreoletti Cristina M. Lanata Laura Trupin Ishan Paranjpe Tia S. Jain Joanne Nititham Kimberly E. Taylor Alexis J. Combes Lenka Maliskova Chun Jimmie Ye Patricia Katz Maria Dall’Era Jinoos Yazdany Lindsey A. Criswell Marina Sirota
author_sort	Gaia Andreoletti
title	Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures
title_short	Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures
title_full	Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures
title_fullStr	Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures
title_full_unstemmed	Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures
title_sort	transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7bed769c8e6e4805aebc706b9462c06e
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Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures

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