The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

ABSTRACT The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebrate niches, which suggests that they have evolved to function under widely different environmental conditions. Using a combination of biophysical and crystallogra...

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Autores principales: Kristin R. Wade, Sara L. Lawrence, Allison J. Farrand, Eileen M. Hotze, Michael J. Kuiper, Michael A. Gorman, Michelle P. Christie, Santosh Panjikar, Craig J. Morton, Michael W. Parker, Rodney K. Tweten
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
cold denaturation
complement
gasdermin
perforin
water network
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/7bf35b5ddc6847bfb07b9a7eda692855
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https://doaj.org/article/7bf35b5ddc6847bfb07b9a7eda692855

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