Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

SUMOylation is known to regulate androgen receptor (AR) activity in cultured cells. Here, using SUMOylation-deficient AR knock-in mice, the authors demonstrate that SUMOylation is required for AR-related gene expression specifically in the epididymal tissues, but not the testis.

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Autores principales: Fu-Ping Zhang, Marjo Malinen, Arfa Mehmood, Tiina Lehtiniemi, Tiina Jääskeläinen, Einari A. Niskanen, Hanna Korhonen, Asta Laiho, Laura L. Elo, Claes Ohlsson, Noora Kotaja, Matti Poutanen, Petra Sipilä, Jorma J. Palvimo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/7bfcbcb37546416dbab210522f05d0c2
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https://doaj.org/article/7bfcbcb37546416dbab210522f05d0c2

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