Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

SUMOylation is known to regulate androgen receptor (AR) activity in cultured cells. Here, using SUMOylation-deficient AR knock-in mice, the authors demonstrate that SUMOylation is required for AR-related gene expression specifically in the epididymal tissues, but not the testis.

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Autores principales:	Fu-Ping Zhang, Marjo Malinen, Arfa Mehmood, Tiina Lehtiniemi, Tiina Jääskeläinen, Einari A. Niskanen, Hanna Korhonen, Asta Laiho, Laura L. Elo, Claes Ohlsson, Noora Kotaja, Matti Poutanen, Petra Sipilä, Jorma J. Palvimo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7bfcbcb37546416dbab210522f05d0c2
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spelling	oai:doaj.org-article:7bfcbcb37546416dbab210522f05d0c22021-12-02T17:01:55ZLack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction10.1038/s41467-019-08730-z2041-1723https://doaj.org/article/7bfcbcb37546416dbab210522f05d0c22019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08730-zhttps://doaj.org/toc/2041-1723SUMOylation is known to regulate androgen receptor (AR) activity in cultured cells. Here, using SUMOylation-deficient AR knock-in mice, the authors demonstrate that SUMOylation is required for AR-related gene expression specifically in the epididymal tissues, but not the testis.Fu-Ping ZhangMarjo MalinenArfa MehmoodTiina LehtiniemiTiina JääskeläinenEinari A. NiskanenHanna KorhonenAsta LaihoLaura L. EloClaes OhlssonNoora KotajaMatti PoutanenPetra SipiläJorma J. PalvimoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fu-Ping Zhang Marjo Malinen Arfa Mehmood Tiina Lehtiniemi Tiina Jääskeläinen Einari A. Niskanen Hanna Korhonen Asta Laiho Laura L. Elo Claes Ohlsson Noora Kotaja Matti Poutanen Petra Sipilä Jorma J. Palvimo Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction
description	SUMOylation is known to regulate androgen receptor (AR) activity in cultured cells. Here, using SUMOylation-deficient AR knock-in mice, the authors demonstrate that SUMOylation is required for AR-related gene expression specifically in the epididymal tissues, but not the testis.
format	article
author	Fu-Ping Zhang Marjo Malinen Arfa Mehmood Tiina Lehtiniemi Tiina Jääskeläinen Einari A. Niskanen Hanna Korhonen Asta Laiho Laura L. Elo Claes Ohlsson Noora Kotaja Matti Poutanen Petra Sipilä Jorma J. Palvimo
author_facet	Fu-Ping Zhang Marjo Malinen Arfa Mehmood Tiina Lehtiniemi Tiina Jääskeläinen Einari A. Niskanen Hanna Korhonen Asta Laiho Laura L. Elo Claes Ohlsson Noora Kotaja Matti Poutanen Petra Sipilä Jorma J. Palvimo
author_sort	Fu-Ping Zhang
title	Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction
title_short	Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction
title_full	Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction
title_fullStr	Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction
title_full_unstemmed	Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction
title_sort	lack of androgen receptor sumoylation results in male infertility due to epididymal dysfunction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7bfcbcb37546416dbab210522f05d0c2
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Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

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