Identification of small-molecule inhibitors of Yersinia pestis Type III secretion system YscN ATPase.

Yersinia pestis is a gram negative zoonotic pathogen responsible for causing bubonic and pneumonic plague in humans. The pathogen uses a type III secretion system (T3SS) to deliver virulence factors directly from bacterium into host mammalian cells. The system contains a single ATPase, YscN, necessa...

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Autores principales: Wieslaw Swietnicki, Daniel Carmany, Michael Retford, Mark Guelta, Russell Dorsey, Joel Bozue, Michael S Lee, Mark A Olson
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/7c1ce5f18a864337a77e8ef9795e8d6b
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