Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons

Optogenetic approaches for inducing TDP-43 aggregation have been described previously in cellular models. Here the authors develop an approach to optogenetically induce TDP-43 aggregation in vivo using zebrafish to model ALS pathologies.

Guardado en:

Detalles Bibliográficos
Autores principales:	Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7c6b2200d5b548f9a33410547da5f71f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7c6b2200d5b548f9a33410547da5f71f
record_format	dspace
spelling	oai:doaj.org-article:7c6b2200d5b548f9a33410547da5f71f2021-12-02T14:42:13ZOptogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons10.1038/s41467-020-14815-x2041-1723https://doaj.org/article/7c6b2200d5b548f9a33410547da5f71f2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14815-xhttps://doaj.org/toc/2041-1723Optogenetic approaches for inducing TDP-43 aggregation have been described previously in cellular models. Here the authors develop an approach to optogenetically induce TDP-43 aggregation in vivo using zebrafish to model ALS pathologies.Kazuhide AsakawaHiroshi HandaKoichi KawakamiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazuhide Asakawa Hiroshi Handa Koichi Kawakami Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons
description	Optogenetic approaches for inducing TDP-43 aggregation have been described previously in cellular models. Here the authors develop an approach to optogenetically induce TDP-43 aggregation in vivo using zebrafish to model ALS pathologies.
format	article
author	Kazuhide Asakawa Hiroshi Handa Koichi Kawakami
author_facet	Kazuhide Asakawa Hiroshi Handa Koichi Kawakami
author_sort	Kazuhide Asakawa
title	Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons
title_short	Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons
title_full	Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons
title_fullStr	Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons
title_full_unstemmed	Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons
title_sort	optogenetic modulation of tdp-43 oligomerization accelerates als-related pathologies in the spinal motor neurons
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7c6b2200d5b548f9a33410547da5f71f
work_keys_str_mv	AT kazuhideasakawa optogeneticmodulationoftdp43oligomerizationacceleratesalsrelatedpathologiesinthespinalmotorneurons AT hiroshihanda optogeneticmodulationoftdp43oligomerizationacceleratesalsrelatedpathologiesinthespinalmotorneurons AT koichikawakami optogeneticmodulationoftdp43oligomerizationacceleratesalsrelatedpathologiesinthespinalmotorneurons
_version_	1718389759882035200

Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons

Ejemplares similares