Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma

Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma

Abstract Glaucoma of which primary open angle glaucoma (POAG) constitutes 75%, is the second leading cause of blindness. Elevated intra ocular pressure and Nitric oxide synthase (NOS) dysfunction are hallmarks of POAG. We analyzed clinical data, cytokine profile, ATP level, metabolomics and GEO data...

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Main Authors: Sujith Kumar Pulukool, Sai Krishna Srimadh Bhagavatham, Vishnu Kannan, Piruthivi Sukumar, Rajesh Babu Dandamudi, Shamika Ghaisas, Haripriya Kunchala, Darshan Saieesh, Ashwin Ashok Naik, Ashish Pargaonkar, Anuj Sharma, Venketesh Sivaramakrishnan
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/7c8d5e80c6984f2a9a441ababc5e7595
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