Immunological exhaustion: How to make a disparate concept operational?

In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to cl...

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Main Authors:	Hannah Kaminski, Maël Lemoine, Thomas Pradeu
Format:	article
Language:	EN
Published:	Public Library of Science (PLoS) 2021
Subjects:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/7c9f7c7ca4b0450b9b0faa8c78f88d68
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spelling	oai:doaj.org-article:7c9f7c7ca4b0450b9b0faa8c78f88d682021-12-02T20:00:07ZImmunological exhaustion: How to make a disparate concept operational?1553-73661553-737410.1371/journal.ppat.1009892https://doaj.org/article/7c9f7c7ca4b0450b9b0faa8c78f88d682021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009892https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.Hannah KaminskiMaël LemoineThomas PradeuPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 9, p e1009892 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Hannah Kaminski Maël Lemoine Thomas Pradeu Immunological exhaustion: How to make a disparate concept operational?
description	In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.
format	article
author	Hannah Kaminski Maël Lemoine Thomas Pradeu
author_facet	Hannah Kaminski Maël Lemoine Thomas Pradeu
author_sort	Hannah Kaminski
title	Immunological exhaustion: How to make a disparate concept operational?
title_short	Immunological exhaustion: How to make a disparate concept operational?
title_full	Immunological exhaustion: How to make a disparate concept operational?
title_fullStr	Immunological exhaustion: How to make a disparate concept operational?
title_full_unstemmed	Immunological exhaustion: How to make a disparate concept operational?
title_sort	immunological exhaustion: how to make a disparate concept operational?
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7c9f7c7ca4b0450b9b0faa8c78f88d68
work_keys_str_mv	AT hannahkaminski immunologicalexhaustionhowtomakeadisparateconceptoperational AT maellemoine immunologicalexhaustionhowtomakeadisparateconceptoperational AT thomaspradeu immunologicalexhaustionhowtomakeadisparateconceptoperational
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Immunological exhaustion: How to make a disparate concept operational?

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